BMKGENE provided transcriptome sequencing service for the study “A cascade nanoreactor for enhancing sonodynamic therapy on colorectal cancer via synergistic ROS augment and autophagy blockage“, which was published in Nano Today.
This study aims to improve the antitumor efficiency of sonodynamic therapy (SDT) on colorectal cancer, rationally designing a cascade nanoreactor by incorporating sonosensitizer Ce6 and autophagy inhibitor chloroquine into the homologous tumor cell membrane-modified hollow polydopamine nanocarrier that is pre-doped with platinum nanozymes (designated as CCP@HP@M).
The RNA-seq analyses also confirmed apoptosis and ferroptosis pathways involved in the CCP@HP@M treatment. This cascade nanoreactor will provide a promising strategy for augmenting SDT eradication against tumors by modulation of ROS and autophagy.
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Post time: Sep-08-2023